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1

Thermofluor-based high-throughput stability optimization of proteins for structural studies

Ulrika B. Ericsson, B. Martin Hallberg, George T. DeTitta, Niek Dekker, Pär Nordlund

Journal:

Analytical Biochemistry

Year:

2006

Language:

english

File:

PDF, 374 KB

english, 2006

2

Experiences with HANGMAN: a macromolecular hanging drop vapor diffusion technique

Joseph R. Luft, Vivian Cody, George T. DeTitta

Journal:

Journal of Crystal Growth

Year:

1992

Language:

english

File:

PDF, 6.86 MB

english, 1992

3

Macromolecular crystallization in a high throughput laboratory—the search phase

Joseph R Luft, Jennifer Wolfley, Igor Jurisica, Janice Glasgow, Suzanne Fortier, George T DeTitta

Journal:

Journal of Crystal Growth

Year:

2001

Language:

english

File:

PDF, 86 KB

english, 2001

4

Preface

George T DeTitta

Journal:

Journal of Crystal Growth

Year:

2001

Language:

english

File:

PDF, 41 KB

english, 2001

5

Microbatch macromolecular crystallization on a thermal gradient

Joseph R. Luft, Dawn M. Rak, George T. DeTitta

Journal:

Journal of Crystal Growth

Year:

1999

Language:

english

File:

PDF, 58 KB

english, 1999

6

Microbatch macromolecular crystallization in micropipettes

Joseph R. Luft, Dawn M. Rak, George T. DeTitta

Journal:

Journal of Crystal Growth

Year:

1999

Language:

english

File:

PDF, 475 KB

english, 1999

7

Determination and application of empirically derived detergent phase boundaries to effectively crystallize membrane proteins

Mary Koszelak-Rosenblum, Adam Krol, Namrita Mozumdar, Kristin Wunsch, Adam Ferin, Eleanor Cook, Christina K. Veatch, Raymond Nagel, Joseph R. Luft, George T. DeTitta, Michael G. Malkowski

Journal:

Protein Science

Year:

2009

Language:

english

File:

PDF, 712 KB

english, 2009

8

The molecular conformation of clonidine hydrochloride, an α-adrenergic agonist

Vivian Cody, George T. DeTitta

Journal:

Journal of Chemical Crystallography

Year:

1979

Language:

english

File:

PDF, 482 KB

english, 1979

9

Heterologous expression ofL. majorproteins inS. cerevisiae: a test of solubility, purity, and gene recoding

Erin Quartley, Andrei Alexandrov, Maryann Mikucki, Frederick S. Buckner, Wim G. Hol, George T. DeTitta, Eric M. Phizicky, Elizabeth J. Grayhack

Journal:

Journal of Structural and Functional Genomics

Year:

2009

Language:

english

File:

PDF, 476 KB

english, 2009

10

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Tracy L. Arakaki, Frederick S. Buckner, J. Robert Gillespie, Nicholas A. Malmquist, Margaret A. Phillips, Oleksandr Kalyuzhniy, Joseph R. Luft, George T. DeTitta, Christophe L. M. J. Verlinde, Wesley

Journal:

Molecular Microbiology

Year:

2008

Language:

english

File:

PDF, 703 KB

english, 2008

11

The Crystal Structure of MT0146/CbiT Suggests that the Putative Precorrin-8w Decarboxylase Is a Methyltransferase

Jacob P. Keller, Paul M. Smith, Jordi Benach, Dinesh Christendat, George T. deTitta, John F. Hunt

Journal:

Year:

2002

Language:

english

File:

PDF, 1.18 MB

english, 2002

12

Structures of Substrate- and Inhibitor-Bound Adenosine Deaminase from a Human Malaria Parasite Show a Dramatic Conformational Change and Shed Light on Drug Selectivity

Eric T. Larson, Wei Deng, Brian E. Krumm, Alberto Napuli, Natascha Mueller, Wesley C. Van Voorhis, Frederick S. Buckner, Erkang Fan, Angela Lauricella, George DeTitta, Joseph Luft, Frank Zucker, Wim G

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 2.73 MB

english, 2008

13

The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase

Eric T. Larson, Devaraja G. Mudeppa, J. Robert Gillespie, Natascha Mueller, Alberto J. Napuli, Jennifer A. Arif, Jenni Ross, Tracy L. Arakaki, Angela Lauricella, George DeTitta, Joseph Luft, Frank Zuc

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.99 MB

english, 2010

14

Purification of transmembrane proteins from Saccharomyces cerevisiae for X-ray crystallography

Kathleen M. Clark, Nadia Fedoriw, Katrina Robinson, Sara M. Connelly, Joan Randles, Michael G. Malkowski, George T. DeTitta, Mark E. Dumont

Journal:

Protein Expression and Purification

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

15

A deliberate approach to screening for initial crystallization conditions of biological macromolecules

Joseph R Luft, Robert J Collins, Nancy A Fehrman, Angela M Lauricella, Christina K Veatch, George T DeTitta

Journal:

Journal of Structural Biology

Year:

2003

Language:

english

File:

PDF, 384 KB

english, 2003

16

Crystallographic Investigations of Biotin and Carboxybiotin Derivatives

WILLIAM STALLINGS, GEORGE T. DETITTA

Journal:

Annals of the New York Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 789 KB

english, 1985

17

Lessons from high-throughput protein crystallization screening: 10 years of practical experience

Luft, Joseph R, Snell, Edward H, DeTitta, George T

Journal:

Expert Opinion on Drug Discovery

Year:

2011

Language:

english

File:

PDF, 2.45 MB

english, 2011

18

Molecular conformation of prostaglandin A1 monoclinic cyrstalline polymorph

George T. DeTitta, James W. Edmonds, William L. Duax

Journal:

Year:

1975

Language:

english

File:

PDF, 301 KB

english, 1975

19

Symmetry in prostaglandins: A critical comment

George T. DeTitta, Mary Erman, Suzanne Fortier, Mary Fronckowiak, David Langs

Journal:

Year:

1977

Language:

english

File:

PDF, 182 KB

english, 1977

20

High-Resolution X-ray Diffraction and ab Initio Quantum Chemical Studies of Glycoluril, a Biotin Analog

Li, Naiyin, Maluendes, Sergio, Blessing, Robert H., Dupuis, Michel, Moss, Grant R., DeTitta, George T.

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 1.53 MB

english, 1994

21

[Part 2: Biological Sciences] || Carboxybiotin Translocation Mechanisms Suggested by Diffraction Studies of Biotin and Its Vitamers

George T. DeTitta, R. Parthasarathy, Robert H. Blessing and William Stallings

Journal:

Proceedings of the National Academy of Sciences

Year:

1980

Language:

english

File:

PDF, 804 KB

english, 1980

22

[Part 2: Biological Sciences] || Molecular Structure and Intermolecular Interactions of N1′-Methoxycarbonylbiotin Methyl Ester: A Model for Carboxybiotin

William C. Stallings, C. T. Monti, M. Daniel Lane and George T. DeTitta

Journal:

Proceedings of the National Academy of Sciences

Year:

1980

Language:

english

File:

PDF, 758 KB

english, 1980

23

Prostaglandins PGA1 and PGB1. Crystallographic studies of the conformational requirements for 15-hydroxyprostaglandin dehydrogenase activity

DeTitta, George T., Langs, David A., Edmonds, James W.

Journal:

Year:

1979

Language:

english

File:

PDF, 539 KB

english, 1979

24

Crystal and molecular structure of d,l-dethiobiotin. Role of sulfur in biotin stereochemistry

Chen, Cheng-San, Parthasarathy, R., DeTitta, George T.

Journal:

Journal of the American Chemical Society

Year:

1976

Language:

english

File:

PDF, 913 KB

english, 1976

25

Total synthesis of (.+-.)-eriolanin

Grieco, Paul A., Oguri, Tomei, Gilman, S., DeTitta, George T.

Journal:

Journal of the American Chemical Society

Year:

1978

Language:

english

File:

PDF, 364 KB

english, 1978

26

Using Fragment Cocktail Crystallography To Assist Inhibitor Design of Trypanosoma brucei Nucleoside 2-Deoxyribosyltransferase †

Bosch, Jürgen, Robien, Mark A., Mehlin, Christopher, Boni, Erica, Riechers, Aaron, Buckner, Frederick S., Van Voorhis, Wesley C., Myler, Peter J., Worthey, Elizabeth A., DeTitta, George, Luft, Joseph

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 736 KB

english, 2006

27

Molecular structure of biotin. Results of two independent crystal structure investigations

DeTitta, George T., Edmonds, James W., Stallings, William, Donohue, Jerry

Journal:

Journal of the American Chemical Society

Year:

1976

Language:

english

File:

PDF, 896 KB

english, 1976

28

Chirality of intermediates in thiamin catalysis: structure of (+)-2-(1-hydroxyethyl)-3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide, the absolute stereochemistry of the enantiomers of 2-(1-hydroxyethyl)thiamin, and enzymic reaction of the diphosphates

Kluger, Ronald, Karimian, Khashayar, Gish, Gerald, Pangborn, Walter A., DeTitta, George T.

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 394 KB

english, 1987

29

Inherent Conformation of the Biotin Bicyclic Moiety: Searching for a Role for Sulfur

DeTitta, George T., Blessing, Robert H., Moss, Grant R., King, Harry F., Sukumaran, Dinesh K., Roskwitalski, Raymond L.

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 864 KB

english, 1994

30

Structure, absolute configuration, and synthesis of stramonin-B, a new cytotoxic pseudoguaianolide

Grieco, Paul A., Oguri, Tomei, Burke, Steven, Rodriguez, Eloy, DeTitta, George T., Fortier, Suzanne

Journal:

Journal of Organic Chemistry

Year:

1978

Language:

english

File:

PDF, 442 KB

english, 1978

31

Cholesteryl myristate: structures of the crystalline solid and mesophases

Craven, Bryan M., DeTitta, George T.

Journal:

Journal of the Chemical Society Perkin Transactions 2

Year:

1976

Language:

english

File:

PDF, 1.25 MB

english, 1976

32

[American Institute of Aeronautics and Astronautics 2001 Conference and Exhibit on International Space Station Utilization - Cape Canaveral,FL,U.S.A. (15 October 2001 - 18 October 2001)] 2001 Conference and Exhibit on International Space Station Utilization - Macromolecular crystallization in a high throughput setting

Pangborn, Walter, Collins, Robert, Kaczmarek, Jillian, Luft, Joseph, e, al, Bianca, Melissa, Wolfley, Jennifer, Faust, Anne Marie, Fehrman, Nancy, Salerno, Jeffrey, DeTitta, George

Year:

2001

Language:

english

File:

PDF, 369 KB

english, 2001

33

ChemInform Abstract: MOLECULAR STRUCTURE OF BIOTIN. RESULTS OF TWO INDEPENDENT CRYSTAL STRUCTURE INVESTIGATIONS

DETITTA, GEORGE T., EDMONS, JAMES W., STALLINGS, WILLIAM, DONOHUE, JERRY

Journal:

Chemischer Informationsdienst

Year:

1976

File:

PDF, 98 KB

1976